Preparation of a colon-specific sustained-release capsule with curcumin-loaded SMEDDS alginate beads

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Preparation of a colon-specific sustained-release capsule with curcumin-loaded SMEDDS alginate beads

A colon-specific capsule with alginate beads containing a self-microemulsifying drug delivery system (SMEDDS) was developed and evaluated. The SMEDDS technique was used to improve the solubility of curcumin (Cur). After encapsulating the Cur-loaded SMEDDS, the alginate beads were placed inside an impermeable capsule body. A konjac glucomannan/lactose/hydroxypropyl methylcellulose (KG/Lac/ HPMC)...

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ژورنال

عنوان ژورنال: RSC Advances

سال: 2017

ISSN: 2046-2069

DOI: 10.1039/c6ra27693h